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Searching information on drug research projects

This database contains information gathered in the course of the ERANID project during 2013 and 2014. Principally, it contains details of research projects on illicit drugs carried out since 2010 within the six ERANID countries and funded by the European Committee: Belgium; France; Italy; Portugal; The Netherlands; and the United Kingdom. However, this database will not capture all illicit drugs research carried out within a country.

36 projects matched the selected criteria:

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Drug Prices

Funding country
Italy
Project starting year
2011
Project ending year
2013
Area(s) of research
Supply and markets
Objectives
Objective of this project is to define and test procedures used for collection, elaboration and archiving of data, for the transmission of them by the DCSA to the Department for Anti-drugs Policies (DPA, to be entered into the database of the DPA for internal use, to supply European surveys handled by the EMCDDA and to be published on a website.
Scientific discipline(s) involved
Neurosciences, Sociology
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Initial identified needs
The project responds to the lack of a dataset relative to wholesale and retail prices of substances, useful to estimate with sufficient analyticity and periodicity of "purity adjusted" values relatively to the Italian context.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM - Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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Exposure to cannabinoids during adolescence and development of cocaine and heroin addiction in adulthood

Funding country
Italy
Project starting year
2012
Project ending year
2013
Area(s) of research
Prevention responses, Treatment responses, Consequences of drug use
Objectives
To investigate the consequences of exposure to cannabinoids during adolescence and subsequent development of addiction to heroin and cocaine in the rat
Scientific discipline(s) involved
Neurosciences, Pharmacology, Other medical sciences, Other discipline, Psychiatry
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Initial identified needs
Cannabinoids are widely used especially during adolescence. It is unclear whether their chronic use can contribute to shape vulnerability for other drugs of abuse in the future.
Performed by
University of Camrino
Funded by
Dipartimento delle Politiche Antidroga
Summary references
I derivati della cannabis sono fra le sostanze illecite più diffusamente utilizzate in età periadolescenziale. Nella letteratura scientifica il potenziale di abuso del Δ9-THC (THC) e’ ben documentato; meno note sono le conseguenze dell’esposizione cronica a questa sostanza in età giovanile e l’insorgenza di patologie della sfera psichica e cognitiva. Studi condotti dal nostro laboratorio nell’ambito del programma IMPACT hanno dimostrato che nel ratto l’esposizione cronica al THC evoca un aumento della risposta ansiosa anche a distanza di vari giorni dalla interruzione dell’esposizione al THC (Stopponi et al 2011). Concomitantemente a questi effetti comportamentali sono stati osservati cambiamenti a livello corticale cerebrale nell’espressione di numerosi geni coinvolti nei meccanismi della neuroinfiammazione e dello stress. Fra questi spicca, ad esempio, l’elevata espressione dei trascritti per recettore dell’interleuchina-1, della proteina induttrice del fattore di necrosi tissulate α (TNF α). Cosa ancora più interessante e’ che gli animali esposti al THC cronico in età periadolescenziale, se allenati ad autosomministrasi eroina in età adulta manifestano un aumento della vulnerabilità allo sviluppo di dipendenza da essa (Stopponi et al, in preparazione). In particolare, e’ stato osservato che pur avendo, questi animali un assunzione di eroina simile a quella dei controlli (trattati con veicolo del THC) risultano essere marcatamente più vulnerabili alla ricaduta all’abuso indotta dall’esposizione a stress. Questa osservazione e’ di notevolissima importanza scientifica poiché in letteratura molti lavori basati su parametri di assunzione di farmaci di abuso (per esempio auto somministrazione endovenosa nel ratto) sollevano dubbi sul significato reale della “gateway hypothesis” per il THC. I nostri risultati invece, pur confermando che l’uso precoce del THC non aumenta il consumo di eroina in età adulta, hanno dimostrato che esso aumenta drammaticamente il rischio di ricaduta rendendo quindi la spirale della dipendenza più perniciosa e difficilmente trattabile. Questa osservazione e’ stata possibile poiché il nostro lavoro e’ stato il primo a valutare la vulnerabilità alla ricaduta da stress in animali precedentemente trattati con THC cronico.
Website
Published reference(s)
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GENERISK2 - Evaluation of genetic vulnerability - identification of risk factors relating to the abuse of cannabis and related psychiatric disorders

Funding country
Italy
Project starting year
2012
Project ending year
2013
Area(s) of research
Determinants of drug use
Objectives
The project intends to address the problem of vulnerability to develop drug addiction with the analysis of genetic polymorphisms that may affect the functionality of the biochemical pathway of the cannabis utilization, behavioral and psychological aspects of interpersonal influences that are deemed relevant to facilitating contacts and / or consolidation of consumption. The polymorphisms of the genes chosen for the study are those involved, according to the literature, in determining the tone of the endogenous cannabinoid and dopamine that has complex interactions with the endocannabinoids pathway. The identification of genetic and environmental factors such as the risk factors relating to the vulnerability to cannabinoids and related psychiatric disorders will enable the realization of initiatives preventive greater impact and higher in the fight against substance abuse.
Scientific discipline(s) involved
Other discipline
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Initial identified needs
The vulnerability to develop addiction is influenced by a combination of genetic and environmental factors. The new model that is emerging in the field of behavioral genetics suggests that the study should address the impact on the behavior not of a single gene but rather should examine which genes and environment determine human behavior. The association may be the result from a combination of several polymorphisms at risk and / or may be mediated by environmental factors such as conditions of trauma, emotional abuse and neglect, perception of parental care and parent-child attachment, adverse experiences during childhood and adolescence. These and other environmental factors may favor those alterations of the system of gratification, impulse control and decision-making of the processing of emotions, creating an ideal breeding ground for the establishment of addition. Moreover it appears that cannabis is able to induce psychotic disorders, that consumers assiduous present a three fold higher risk of developing schizophrenia spectrum disorders, and that the development of a schizophrenic disorder after taking cannabis derivatives is related to the familiar for psychotic disorders. It follows that a genetic predisposition definitely makes relevant the identification of individuals at risk for preventive actions that encourage the acquisition of positive behaviors and useful for the preservation of health.
Performed by
Addiction Service (SERT) Biella, Italy
Addiction Service (SERT) Roma C, Italy
Addiction Service (SERT) Bologna, Italy
Addiction Service (SERT) Cosenza, Italy
Addiction Service (SERT) Parma, Italy
Funded by
Department of Drug Control Policy - Presidency of the Council of Ministers
Summary references
Arendt M, Mortensen PB, Rosenberg R, Pedersen CB, Waltoft BL. (2008) Familial predisposition for psychiatric disorder: comparison of subjects treated for cannabis-induced psychosis and schizophrenia. Arch Gen Psychiatry 65:1269-1274 Chiang KP, Gerber AL, Sipe JC, Cravatt B. (2004) Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Hum Mol Genet 13:2113-2119. Comings DE, Muhleman D, Gade R, Johnson P, Verde R, Saucier G, MacMurray J. (1997) Cannabinoid receptor gene (CNR1): association with i.v. drug use. Mol Psychiatry 2:161-168. Covault J, Gelernter J, Kranzler H.(2001) Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. Mol Psychiatry 6:501-502. Duan J, Wainwright MS, Comeron JM, Saitou N, Sanders AR, Gelernter J, Gejman PV. (2003) Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 12:205-216. Flanagan JM, Gerber AL, Cadet JL, Beutler E, Sipe JC. (2006) The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. Hum Genet 120:581-588. Gadzicki D, Müller-Vahl K, Stuhrmann M. (1999) A frequent polymorphism in the coding exon of the human cannabinoid receptor (CNR1) gene. Mol Cell Probes 3:321-323. Gerra G, Garofano L., Pellegrini C, Bosari S, Zaimovic A, Moi G, Avanzini P, Talarico E, Gardini F, Donnini C. (2005) Allelic association of a dopamine transporter gene polymorphism with antisocial behavior in heroin dependent patients: a preliminary explorative analysis. Addiction Biology 10: 275-281 Guindalini C, Howard M, Haddley K, Laranjeira R, Collier D, Ammar N, Craig I, O'Gara C, Bubb VJ, Greenwood T, Kelsoe J, Asherson P, Murray RM, Castelo A, Quinn JP, Vallada H, Breen G. (2006) A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci U S A 103:4552-4557. Hamer D. (2002) Genetics. Rethinking behavior genetics. Science 298:71-72. Hartman CA, Hopfer CJ, Haberstick B, Rhee SH, Crowley TJ, Corley RP, Hewitt JK, Ehringer MA. (2009) The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults. Drug Alcohol Depend 104:11-16. Haughey HM, Marshall E, Schacht JP, Louis A, Hutchison KE. (2008) Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes. Addiction 103:1678-1686. Heller D, Schneider U, Seifert J, Cimander KF, Stuhrmann M. (2001) The cannabinoid receptor gene (CNR1) is not affected in German i.v. drug users. Addict Biol 6:183-187. Herman AI, Kranzler HR, Cubells JF, Gelernter J, Covault J. (2006) Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence. Am J Med Genet B Neuropsychiatr Genet. 141B:499-503. Hill SY, Hoffman EK, Zezza N, Thalamuthu A, Weeks DE, Matthews AG, Mukhopadhyay I. (2008) Dopaminergic mutations: within-family association and linkage in multiplex alcohol dependence families. Am J Med Genet B Neuropsychiatr Genet. 147B:517-526 Hirvonen MM, Laakso A, Någren K, Rinne JO, Pohjalainen T, Hietala J. 2009 C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity. Synapse 63:907-912. Hopfer CJ, Young SE, Purcell S, Crowley TJ, Stallings MC, Corley RP, Rhee SH, Smolen A, Krauter K, Hewitt JK, Ehringer MA. (2006) Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents. Am J Med Genet B Neuropsychiatr Genet. 141B:895-901. Johnston LD, O’Malley PM, Bachman JG, Schulenberg JE. (2004) Moni
Website
http://www.neuroscienzedipendenze.it/generisk.html
Published reference(s)
The project is ongoing and no data have yet been published
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Key Indicator

Funding country
Italy
Project starting year
2012
Project ending year
2013
Area(s) of research
Prevention responses, Supply and markets, Methodology issues
Objectives
The goal of the project is to monitor the consumption of drugs in young people, both in quantitative terms (students involved), both with reference to the characteristics of the consumers, and in order to meet the annual commitment towards the European Observatory through the implementation of an annual study in the Italian high school population (15-19 years).
Scientific discipline(s) involved
Demography, Neurosciences, Political sciences, Sociology
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Initial identified needs
The monitoring of the consumption of legal and illegal psychotropic substances in Europe has taken a strategic role in the fight against the spread of the phenomenon. Only through a continuous and constant observation of the evolution of consumption and of other factors related to supply and demand of drugs it is possible to collect useful information for the definition of new and effective Anti-drugs strategies and policies.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM - Consorzio di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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NNIDAC-National Network for preventing road accidents. Correlates to drugs and alcohol

NNIDAC - Network Nazionale per la prevenzione degli Incidenti stradali Droga e Alcol Correlati
Funding country
Italy
Project starting year
2011
Project ending year
2013
Area(s) of research
Prevention responses, Harm reduction responses, Determinants of drug use, Consequences of drug use, Mechanism of drug use and effects, Methodology issues
Objectives
Disseminate and consolidate the implementation of the "DOS Procedure" or of similar methodologies that aim to address the problem of driving under the effect of alcohol and drugs, proposing a feasible and effective methodology to perform clinical and toxicological tests.
Scientific discipline(s) involved
Neurosciences, Sociology, Pharmacology
Read more…
Initial identified needs
The project responds to the need to adopt the "DOS (Drugs on Street) Procedure" in the Italian Municipalities
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies, CUEIM - Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
http://www.drugsonstreet.it/presentazione/NNIDAC.html
Published reference(s)
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Noi No! (Not us!)

Noi No!
Funding country
Italy
Project starting year
2012
Project ending year
2013
Area(s) of research
Prevention responses, Drug related crime responses, Determinants of drug use, Consequences of drug use, Supply and markets
Objectives
The objective of the project is to spread among the widest range of young people a message able to make them aware of their responsibilities on the existence of a relationship between drugs consumption and the activities of criminal organizations.
Scientific discipline(s) involved
Neurosciences, Political sciences, Sociology
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Initial identified needs
The project responds to the need to raise awareness that the use of drugs, even if only occasionally, involves the entry into relationship and collusion with national and international criminal organizations involved in drugs trafficking.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM-Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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PINS - Ci stai contro la droga?

Funding country
Italy
Project starting year
2011
Project ending year
2013
Area(s) of research
Prevention responses, Determinants of drug use, Consequences of drug use, Methodology issues
Objectives
The goal of the project is to define a methodology able to sensitize young people about the importance of leading a healthy lifestyle, offering them the opportunity to reflect on issues concerning drug addiction and on the damage associated with it.
Scientific discipline(s) involved
Political sciences, Sociology
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Initial identified needs
Given the widespread consumption of psychoactive substances and the high number of alcohol and drugs related traffic accidents involving youngsters aged between 15 and 19 years, the project responds to the need to address the problem by making young people more informed of the risks of drugs consumption. It is believed that encouraging students to produce communication messages make them more aware on the issue.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM - Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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Preventing

Prevenire
Funding country
Italy
Project starting year
2012
Project ending year
2013
Area(s) of research
Prevention responses, Determinants of drug use, Consequences of drug use, Supply and markets
Objectives
The project aims at designing and implementing new information materials against the use of drugs targeted to teachers, students and parents. These materials should meet the demand for information and education that comes from the target groups, encouraging the spread of scientifically correct information for the prevention of drug abuse in young people.
Scientific discipline(s) involved
Neurosciences, Sociology
Read more…
Initial identified needs
The project responds to the need to continue to invest in activities that maintain the results that have been achieved in drugs prevention, enhancing them. In particular, there is the need to work on targeted interventions aimed at preventing the consumption of drugs by young people.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM - Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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Promo Eurodrugs II

Funding country
Italy
Project starting year
2012
Project ending year
2013
Area(s) of research
Methodology issues
Objectives
The project objective is to support the innovation and to increase the efficiency and effectiveness of the policies of the Department for Anti-drugs Policies (DPA), strengthening regional actions, visibility and integration at European level. The project aims at the creation of networks for experimental projects through continuing education of local operators with advanced skills in project design, proposal management and project management in the use of the European Community resources.
Scientific discipline(s) involved
Political sciences, Sociology
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Initial identified needs
Despite Italy present many European projects, only some of them are eligible for funding. This situation is caused both by the lack of strong partnerships which meet the European requirements and for the difficulty to create networks in which tasks and resources are shared equally between all partners. A further difficulty is the lack of synergy between local strategies, national and European.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM - Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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SGS_ the way to a safe driving

SGS - La Strada per una Guida Sicura
Funding country
Italy
Project starting year
2011
Project ending year
2013
Area(s) of research
Law enforcement responses, Determinants of drug use, Consequences of drug use, Mechanism of drug use and effects
Objectives
The objective of the project is to raise awareness among young people about the importance of safe driving and to offer them, through the production of a specific spot-video, a further opportunity for reflection on issues related to road safety and to the measures to be taken to prevent the dangers related to driving under the influence of alcohol and drugs.
Scientific discipline(s) involved
Neurosciences, Sociology
Read more…
Initial identified needs
The project responds to the lack of programs and prevention activities on the effects that drugs and alcohol have on driving, to the increase in the number of road accidents and sanctions related to the use of drugs and alcohol, to the misinformation about the consequences on the health and on the driving capacity due to the use of drugs, to the lack of a technical and scientific information of the driving school instructors and to the fragmented nature and limited effectiveness of initiatives already realized.
Performed by
CUEIM - University consortium of Industrial and Managerial Economy/ CUEIM-DPA working group
Funded by
Department for Anti-drugs Policies (DPA), CUEIM - Consorzio Universitario di Economia Industriale e Manageriale
Summary references
Website
Published reference(s)
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