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Searching information on drug research projects

This database contains information gathered in the course of the ERANID project during 2013 and 2014. Principally, it contains details of research projects on illicit drugs carried out since 2010 within the six ERANID countries and funded by the European Committee: Belgium; France; Italy; Portugal; The Netherlands; and the United Kingdom. However, this database will not capture all illicit drugs research carried out within a country.

90 projects matched the selected criteria:

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Evaluation of experimental female-oriented addiction care services

Funding country
France
Project starting year
2012
Project ending year
2013
Area(s) of research
Treatment responses, Harm reduction responses
Objectives
To describe the patterns and conditions of implementation of these female-specific drug addiction services and the outreached public To describe the place of the female-oriented drug addiction services in the mainstream care system and the strategies developed to strengthen them within the social and health landscape. To identify practical, deontological or strategic issues identified by providers to date.
Scientific discipline(s) involved
History, Sociology
Read more…
Objectives (native)
-to describe the patterns and conditions of implementation of these female-specific drug addiction services and the outreached public - to describe the place of the female-oriented drug addiction services in the mainstream care system and the strategies developed to strengthen them within the social and health landscape. - to identify practical, deontological or strategic issues identified by providers to date.
Initial identified needs
Protecting the health of the unborn children and the mothers who present drug addiction problems belongs to the governmental objectives established by the plan to fight against drugs and the drug addiction for the period 2008-2011. Integrating the specificities and needs of females misusing alcohol and/or drugs is at stake. In 2009 and 2010, the French National Health Directorate (DGS) and the French Interministerial Mission for the fight against drugs and drug addiction (MILDT) finance about forty experimental projects of care, social integration and/or risk reduction directed to drug-addicted women, in particular mothers or pregnant women. These projects are distributed in four categories: - advanced consultation performed by specialized treatment centres in social housing centres (CHRS) receiving women with children - Specific counseling for the women with children in inpatient drug treatment centres providing collective housing - Specific counseling for the women in out-patient drug treatment and low threshold centres (CSAPA and CAARUD) - Mobile team for mother-child care attached to drug treatment centres CSAPA. In 2012, the DGS and the MILDT jointly commissioned the French Monitoring Centre on Drugs and Drug Addictions (OFDT) to assess the implementation of these experimental services.
Performed by
OFDT (French Monitoring Centre on Drugs and Drug Addictions) - Unit of Public Policies Evaluation
Funded by
OFDT (French Monitoring Centre on Drugs and Drug Addictions)
Summary references
Website
Published reference(s)
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Evaluation of experimental therapeutic collective housing for cocain or crack users

Funding country
France
Project starting year
2012
Project ending year
2013
Area(s) of research
Treatment responses
Objectives
To assessess the patterns and conditions of implementation of this experimental therapeutic collective housing for cocain or crack users To describe the outreached public To describe obstacles encountered by providers and paths to overcome them.
Scientific discipline(s) involved
History, Sociology
Read more…
Initial identified needs
In 2005, France counts 250,000 regular cocaine users at but the number of experimentators has regularly increased since 2000. In 2008, about 3 % of the 17-year-old young people have experimented cocaine. The consumption of cocaine under all its forms seems to spread in all the social backgrounds. The coverage of these users requires some adaptations of the care system. In 2010, the French National Health Directorate (DGS) and the French Interministerial Mission for the fight against drugs and drug addiction (MILDT) financed an experimental project of therapeutic collective housing for cocain or crack users. In 2012, the DGS and the MILDT jointly commissioned the French Monitoring Centre on Drugs and Drug Addictions (OFDT) to assess the implementation of these experimental services.
Performed by
OFDT (French Monitoring Centre on Drugs and Drug Addictions) - Unit of Public Policies Evaluation
Funded by
OFDT (French Monitoring Centre on Drugs and Drug Addictions)
Summary references
Website
Published reference(s)
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Evaluation of fast access and short-term support units for drug addicted prison leavers

Funding country
France
Project starting year
2012
Project ending year
2013
Area(s) of research
Treatment responses, Law enforcement responses
Objectives
To describe the patterns and conditions of implementation of these fast access and short-term support units for drug addicted prison leavers To describe the outreached public To explore possible leverages for the development of such responses, identifying emerging issues (practical, deontological, strategic) raised to date by providers
Scientific discipline(s) involved
History, Sociology
Read more…
Objectives (native)
-to describe the patterns and conditions of implementation of these fast access and short-term support units for drug addicted prison leavers -to describe the outreached public - to explore possible leverages for the development of such responses, identifying emerging issues (practical, deontological, strategic) raised to date by providers
Initial identified needs
Multiple confinements and failures after their release affect some prison leavers to undergone the necessary preparation for their (re)integration or rehabilitation. Difficulties in accessing to housing or in continuing care deteriorate even more their situation. Prison leavers encounter obstacles which prove to be impartially anticipated during incarceration. In 2009 and 2010, the French National Health Directorate (DGS) and the French Interministerial Mission for the fight against drugs and drug addiction (MILDT) finance four collective housing units (about 10 places each) within medico-social structures, aimed at offering to drug addicted prison leavers a fast and facilitated access to support supplied by drug addiction treatment centres, in connection with the prison-assigned hospitals. In 2012, the DGS and the MILDT jointly commissioned the French Monitoring Centre on Drugs and Drug Addictions (OFDT) to assess the implementation of these experimental services.
Performed by
OFDT (French Monitoring Centre on Drugs and Drug Addictions) - Unit of Public Policies Evaluation
Funded by
OFDT (French Monitoring Centre on Drugs and Drug Addictions)
Summary references
Website
Published reference(s)
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Genetic dissection of the function of the glucocorticoid receptor in chronic stress effects on behavioral responses to drugs of abuse.

Dissection génétique de la fonction du récepteur des glucocorticoïdes dans les effet du stress sur les réponses comortementales aux drogues d'abus.
Funding country
France
Project starting year
2010
Project ending year
2013
Area(s) of research
Determinants of drug use, Mechanism of drug use and effects
Objectives
The glucocorticoid receptor (GR) is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. it is important to identifiy for which cellular type the activation of GR influences a specific behaviour. We employed mouse lineages carrying an inactivated GR gene in either dopamine or dopaminoceptive neurons to determine the involvement of this transcription factor. Behavioral responses to addictive drugs (sensitization, CPP, self-administration), transition towards addiction and stress-induced behaviours (anxiety, depression, attention, working memory) were studied under normal condition and after a stressing event.
Scientific discipline(s) involved
Neurosciences, Pharmacology, Other discipline
Read more…
Objectives (native)
Le GR est ubiquiste. Il est donc essentiel d’arriver à identifier le type cellulaire dans lequel l’activation du GR va influencer un comportement particulier. Nous avons développé des lignées de souris dans lesquelles le gène GR est invalidé dans, les neurones à dopamine ou les neurones dopaminoceptifs. Les réponses aux drogues d’abus (sensibilisation, CPP, auto-administration), la transition vers l’addiction et les comportements influencés par le stress (anxiété, dépression, attention, mémoire de travail) sont étudiés en condition de base ou suite à un stress.
Initial identified needs
Stress causes the release of glucocorticoids (GCs) that orchestrate the appropriate physiological and behavioral responses by activating the GR, a transcription factor. This mechanism allows to adapt the gene expression to changes in environment. While beneficial in normal operation, it can disrupt and lead to serious pathologies: addiction, depression, anxiety. The nature of the cells and the target genes involved is still unknown.
Initial identified needs (native)
Un stress provoque la libération de glucocorticoïdes (GCs) qui orchestrent les réponses physiologiques et comportementales adéquates en activant le GR, un facteur de transcription. Ce mécanisme permet d’adapter l’expression génique aux variations de l’environnement. Bénéfique dans son fonctionnement normal, il peut se dérégler et aboutir à des pathologies graves: addiction, dépression, anxiété. La nature des cellules et les gènes cibles impliqués demeurent méconnus.
Performed by
CNRS-INSERM-UPMC (French National centre for scientific research -National institute for health and medical research-Pierre and Marie Curie University)
Funded by
CNRS, INSERM, ANR
Summary references
Barik J, …, Faure P, Tronche F. Chronic stress triggers social aversion via GR in dopaminoceptive neurons. Science, 339:332-5. Barik J, … Benecke A and Tronche F. GR in dopaminoceptive neurons, key for cocaine, are dispensable for molecular and behavioral morphine responses. Biol Psy, 2010, 68:231-9 Ambroggi F, … Piazza PV, Tronche F. Stress and addiction: GR in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci, 2009 12:247-9.
Website
non
Published reference(s)
Barik J, …, Faure P, Tronche F. Chronic stress triggers social aversion via GR in dopaminoceptive neurons. Science, 339:332-5. Barik J, … Benecke A and Tronche F. GR in dopaminoceptive neurons, key for cocaine, are dispensable for molecular and behavioral morphine responses. Biol Psy, 2010, 68:231-9 Ambroggi F, … Piazza PV, Tronche F. Stress and addiction: GR in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci, 2009 12:247-9.
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International review on problematic cannabis uses: tools for primary care deliverers for their identification and undertaking

Funding country
France
Project starting year
2013
Project ending year
2013
Area(s) of research
Prevention responses, Treatment responses
Objectives
Main objective: to emphasize the tools which primary care professionals can use so as to guide and enhance the undertaking of problematic cannabis use (PCU) at the primary care level, in France and abroad. The purpose of the review based on scientific articles, grey literature, professional reviews of practices, descriptions of tools, etc.) is triple: To identify the validated criteria and tools for the detection of the PCU; To describe the strategies developed to tackle with PCU at the primary acre level; To list the available tools for the addressing of PCU towards specialized (secondary) structures, developed in France (CSAPA, CJC, Hospital centers, etc.) and abroad.
Scientific discipline(s) involved
Other discipline
Read more…
Objectives (native)
Main objective: to emphasize the tools which primary care professionals can use so as to guide and enhance the undertaking of problematic cannabis use (PCU) at the primary care level, in France and abroad. The purpose of the review based on scientific articles, grey literature, professional reviews of practices, descriptions of tools, etc.) is triple: - to identify the validated criteria and tools for the detection of the PCU; - to describe the strategies developed to tackle with PCU at the primary acre level; - to list the available tools for the addressing of PCU towards specialized (secondary) structures, developed in France (CSAPA, CJC, Hospital centers, etc.) and abroad.
Initial identified needs
This review constitutes the preliminary diagnosis which will have to allow to identify, to adapt and to disseminate some tools to support primary care providers (general practitioners, school health agents, other healthcare professionals) in directing problematic cannabis users to specialized care system. This study joins within the Federation Addiction’s objective of sustaining the evolution of the professional practices within the young outpatient drug clinics (CJC), which are attached to treatment and prevention centres (CSAPA) since 2008(circular of February 28, 2008). The Federation Addiction (the commissioner) aims at developing the reflection on the early intervention, in order to favor the articulation between first-line players and the specialised care system, by developing the territorial meshing and the networking between local health professionals.
Performed by
OFDT (French Monitoring Centre on Drugs and Drug Addictions) - Unit of Public Policies Evaluation
Funded by
Fédération Addiction
Summary references
Website
Published reference(s)
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PREVDROG-PRO

PREVDROG-PRO
Funding country
France
Project starting year
2011
Project ending year
2013
Area(s) of research
Prevention responses, Treatment responses, Drug related crime responses, Harm reduction responses, Consequences of drug use, Mechanism of drug use and effects
Objectives
1) Analysis of the socio-historical construction of the use of psychoactive substances (PS) as a risk and of the screening test as a prevention tool in the workplace. 2) Analysis of internal (subject) and external conditions (context) of PS use and screening tests, and their relationship with the working environment. 3) Analysis of the effects and consequences of these practices on work, PS use and the health of the supervisors and tested. 4) Combined analysis of the conditions and effects of screening in order to assess the differences in objectives. 5) Analysis of the effects of an action research in clinical work on the linkages between: working supervisors-PS purpose-screening practices.
Scientific discipline(s) involved
Economy, Political sciences, Psychology, Sociology, Other discipline
Read more…
Objectives (native)
1) Analyse de la construction sociohistorique des usages de substances psychoactives (SPA) comme risque et des dépistages par test comme outil de prévention au travail. 2) Analyse des conditions internes (dans le sujet) et externes (dans le contexte) des usages de SPA et des pratiques de dépistage par test, de leurs liens avec le travail. 3) Analyse des effets et des conséquences de ces pratiques sur le travail, les usages de SPA et la santé des encadrants-testeurs et des testés. 4) Analyse combinée des conditions et des effets du dépistage en vue d’en évaluer les écarts aux objectifs poursuivis. 5) Analyse des effets d’une recherche-action en clinique du travail sur les articulations entre : travail des encadrants-usages de SPA-pratiques de dépistages.
Initial identified needs
The dominant discourse dramatises the use of psychoactive substances in professional circles and stigmatises some substances (alcohol and drugs vs psychotropic drugs) and some users (young people, workers). It presents the lack of drug action plan within companies as a fault and recommends screenings as the responsible measure to be widespread. This voluntarism is based on the dominant representations associating the effects of drugs to risks and the norm work from supervisors and operators to prevention. But how do the psychoactive substances really affect work, and vice versa? How do screening tests affect uses and work, and vice versa? Knowledge is currently too fragmented to answer. This project aims at documenting these issues.
Initial identified needs (native)
le discours dominant dramatise les usages de SPA en milieux professionnels stigmatise certains produits (alcool et drogues VS médicaments psychotropes) et certains consommateurs (les jeunes, les travailleurs). Il présente l'absence de plan antidrogue dans les entreprises comme une faute el les dépistages par tests comme l'action responsable à généraliser. Ce volontarisme s'appuie sur les représentations dominantes des effets des drogues comme risque et d'un travail norme des encadrants et des opérateurs comme prévention. Mais comment les SPA affectent-t-elles réellement le travail, et inversement ? Comment les dépistages affectent-ils les usages et le travail, et inversement ? Comme ressources ou comme contraintes au coeur des arbitrages dynamiques liés aux soucis de santé, de professionnalisme, de respect des prescriptions, des sujets ? Les connaissances sont aujourd'hui trop parcellaires pour répondre. Ce projet vise à apporter et à compléter ce type de connaissances
Performed by
CNAM CRTD
CNRS CRAPE
Funded by
MILDT-INCA
Summary references
Website
Published reference(s)
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Prevalence study of the psychiatric and neurocognitive impairment among monitored HIV and HCV co-infected patients (sub-study ANRS CO13 HEPAVIH)

Étude de la prévalence des troubles psychiatriques et neurocognitifs au cours du suivi de patients co-infectés par le VIH etle VHC (sous-étude ANRS CO13 HEPAVIH)
Funding country
France
Project starting year
2010
Project ending year
2013
Area(s) of research
Prevalence, incidence and patterns of drug use, Prevention responses, Harm reduction responses, Mechanism of drug use and effects
Objectives
The main objective of this study was to evaluate the prevalence of psychiatric disorders in a cohort of subjects coinfected with HIV and HCV. The secondary objectives are: To assess the prevalence of neurocognitive disorders and their relationship to psychiatric disorders, To characterize the observed mood disorders, particularly with regard to emotional reactivity, - and to identify the factors associated with psychiatric disorders. It is a cross-sectional SURVEY on subjects included in the ANRS CO13 HEPAVIH cohort.
Scientific discipline(s) involved
History, Other discipline
Read more…
Objectives (native)
L’objectif principal de cette étude est d’évaluer la prévalence des troubles psychiatriques au sein d’une cohorte de sujets coinfectés par le VIH et le VHC. Les objectifs secondaires sont d‘évaluer la prévalence des troubles neurocognitifs, et leurs liens avec les troubles psychiatriques, de caractériser les troubles de l’humeur observés, notamment sur le plan de la réactivité émotionnelle, et préciser les facteurs associés à l’existence de troubles psychiatriques. Il s’agit d’une étude transversale réalisée auprès des sujets inclus dans la cohorte ANRS CO13 HEPAVIH.
Initial identified needs
The prevalence and determinants of psychiatric and cognitive disorders and addictive behaviours among people co-infected with HIV and HCV are poorly understood. This sub-study aims at evaluating them. It will also identify the socio-behavioural and clinical factors associated with the occurrence of these disorders in order to better identify the "at risk" subgroups, with a preventive purpose.
Initial identified needs (native)
Chez les sujets co-infectés par le VIH et le VHC, les prévalences et déterminants des troubles psychiatriques et cognitifs, ainsi que les conduites addictives sont mal connus. Cette sous étude a pour objectif de les évaluer. Elle identifiera également les facteurs socio-comportementaux ou cliniques associés à la survenue de ces troubles afin de mieux identifier les sous-groupes « à risque », dans un objectif de prévention
Performed by
INSERM U669, Paris
Inserm U912, marseille
Hôpital Cochin, département de Maladies Infectieuses
Inserm U897, Bordeaux
Funded by
ANRS, ABBOTT
Summary references
Website
www.anrs.fr/content/download/786/5258/.../ANRS_CO13_HEPAVIH.pdf
Published reference(s)
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Quantitative analysis of the perception of damages and benefits associated to addictive substance use

Analyse quantitative de perception des dommages et bénéfices associés aux substances addictives
Funding country
France
Project starting year
2010
Project ending year
2013
Area(s) of research
Determinants of drug use, Mechanism of drug use and effects, Methodology issues
Objectives
To get a quantitative evaluation of licit and illicit addictive substances by experts and by a representative sample of the general population , using a specific scale of dammages and benefits.
Scientific discipline(s) involved
Other medical sciences, Other discipline, Statistics or epidemiology
Read more…
Objectives (native)
Obtenir une évaluation quantitative, à partir d'une grille de dommages et de bénéfices précisément définis, de substances addictives licites et illicites, par des experts de l'action et par un échantillon représentatif de la population générale
Initial identified needs
To illustrate the difference between harms associated by experts to the main addictive substances (licit and illicit) and their legal status; to suggest ways to measure the associated benefits ; to compare the general population's perceptions to the experts's ones.
Initial identified needs (native)
Illustrer le différentiel existant entre les dommages associés aux principales substances addictives (licites et illicites) par les experts et leur statut légal ; proposer des mesures de bénéfices associés ; comparer les perceptions en population générale avec celles des experts
Performed by
INSERM UMR 669 - Université Paris Sud
Inserm UMR 988 / CNRS / EHESS / Université Paris Descartes
Funded by
Mairie de Paris, Région Ile de France
Summary references
A damage/benefit evaluation of addictive product use. Bourgain C, Falissard B, Blecha L, Benyamina A, Karila L, Reynaud M. Addiction. 2012 Feb;107(2):441-50. Quantitative damage-benefit evaluation of drug effects: major discrepancies between the general population, users and experts. Reynaud M, Luquiens A, Aubin HJ, Talon C, Bourgain C. J Psychopharmacol. 2013 Jul;27(7):590-9.
Website
Non
Published reference(s)
A damage/benefit evaluation of addictive product use. Bourgain C, Falissard B, Blecha L, Benyamina A, Karila L, Reynaud M. Addiction. 2012 Feb;107(2):441-50. Quantitative damage-benefit evaluation of drug effects: major discrepancies between the general population, users and experts. Reynaud M, Luquiens A, Aubin HJ, Talon C, Bourgain C. J Psychopharmacol. 2013 Jul;27(7):590-9.
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Variability factors of the appropriate methadone doses to reach stability

Facteurts de variabilité des doses de méthadone nécessaires pour atteindre l'équilibre
Funding country
France
Project starting year
2008
Project ending year
2013
Area(s) of research
Treatment responses, Mechanism of drug use and effects
Objectives
Scientific discipline(s) involved
Neurosciences, Psychology, Pharmacology
Read more…
Objectives (native)
APPROCHES PHENOTYPIQUE ET GENOTYPIQUE DES BIOMARQUEURS PHARMACOCINETIQUES ET PHARMACODYNAMIQUES ASSOCIES A CETTE VARIABILITE
Initial identified needs
The variability of the doses of methadone to reach the balance in the substitution treatment is complex, multifactorial and still incompletely understood.
Initial identified needs (native)
Variabilité des doses de méthadone à l'équilibre du traitement de substitution qui est complexe, multifactorielle et encore incompletement comprise.
Performed by
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
INSERM
CNRS
UNIVERSITE PARIS DESCARTES
UNIVERSITE PARIS DIDEROT ; PRES SORBONNE PARIS CITE
Funded by
DRCD AP-HP
Summary references
http://clinicaltrials.gov/ct2/show/NCT00894452?term=VORSPAN&rank=1
Website
non
Published reference(s)
Title: CANDIDATE GENES FOR PHARMACOGENETIC MANAGEMENT OF METHADONE OPTIMAL DOSE Author(s): Vorspan, F.; Ksouda, K.; Delveaux, L. Labat; et al. Source: EUROPEAN PSYCHIATRY Volume: 27 Supplement: 1 Meeting Abstract: P-952 Published: 2012 Title: How to obtain DNA from injection drug users? Author(s): Hajj, Aline; Peoc'h, Katell; Ksouda, Kamilia; et al. Source: CLINICAL CHEMISTRY AND LABORATORY MEDICINE Volume: 49 Issue: 8 Pages: 1391-1392 DOI: 10.1515/CCLM.2011.614 Published: AUG 2011 Title: A Case Report of Transient but Clinically Relevant Interaction between Methadone and Duloxetine: A Reply to McCance-Katz et al. Author(s): Vorspan, Florence; Ksouda, Kamilia; Bloch, Vanessa; et al. Source: AMERICAN JOURNAL ON ADDICTIONS Volume: 19 Issue: 5 Pages: 458-459 DOI: 10.1111/j.1521-0391.2010.00062.x Published: SEP-OCT 2010 Title: Variability of oral methadone dosages in three outpatient clinics in Paris Author(s): Vorspan, F.; Bloch, V.; Mouly, S.; et al. Source: EUROPEAN PSYCHIATRY Volume: 23 Supplement: 2 Pages: S267-S267 DOI: 10.1016/j.eurpsy.2008.01.544 Published: APR 2008
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Young urban homelessness wandering in Bordeaux (French metropolis)

Jeunes errants urbains à Bordeaux.
Funding country
France
Project starting year
2011
Project ending year
2013
Area(s) of research
Prevalence, incidence and patterns of drug use, Treatment responses, Determinants of drug use, Consequences of drug use, Mechanism of drug use and effects, Supply and markets, Methodology issues
Objectives
To study of the history of homeless young people (from the family, residential, social and health satndpoints) . To assess the implementation of an experimental foyer. To study of drug use in groups of homeless youth. To observe the settlement of this foyer in the neighbourhood and to analyse the residents' social representations on the homeless young people, drug use and life on the margins of society.
Scientific discipline(s) involved
Anthropology, Legal sciences, Sociology
Read more…
Objectives (native)
Étude de la trajectoire (familiale, résidentielle, sociale, sanitaire...) des jeunes sans abris. Évaluation de la mise en place du foyer expérimental. Étude de l'usage de drogues dans des groupes de jeunes sans-abris. Observation de l'encastrement du foyer dans le quartier et analyse des représentations des riverains concernant les jeunes sans-abris, l'usage de drogue et la vie marginale.
Initial identified needs
Follow-up of the trajectory of homeless young people addressed by an experimental foyer in the French city of Bordeaux.
Initial identified needs (native)
Suivi de la trajectoire de jeunes sans abris pris en charge par un foyer expérimental à Bordeaux.
Performed by
Centre Émile Durkheim. Comparative political science and sociology. (UMR5116, University of Bordeaux Segalen, Science Po Bordeaux)
Funded by
Fond Expérimentation Jeunesse - Ministère de la jeunesse
Summary references
Website
Published reference(s)
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