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Searching information on drug research projects

This database contains information gathered in the course of the ERANID project during 2013 and 2014. Principally, it contains details of research projects on illicit drugs carried out since 2010 within the six ERANID countries and funded by the European Committee: Belgium; France; Italy; Portugal; The Netherlands; and the United Kingdom. However, this database will not capture all illicit drugs research carried out within a country.

90 projects matched the selected criteria:

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Trajectories of peoples presenting an drug addiction or a behavioural addiction and addressing the care system. Medical, neurobiological, sociological and psychological characteristics. A prospective multicentric and multidisciplinary study.

Trajectoires de personnes présentant une addiction aux substances ou une addiction comportementale, en contact avec le dispositif de soins. Caractéristiques médicales, neurobiologiques, sociologiques et psychologiques. Etude prospective multicentrique, multidisciplinaire.
Funding country
France
Project starting year
1994
Project ending year
2014
Area(s) of research
Prevalence, incidence and patterns of drug use, Prevention responses, Treatment responses, Law enforcement responses, Harm reduction responses, Determinants of drug use, Consequences of drug use, Mechanism of drug use and effects, Methodology issues
Objectives
To describe the determining factors of addictions among people adressing help services with regrd to at least one type of addiction
Scientific discipline(s) involved
History, Neurosciences, Psychology, Sociology, Other medical sciences, Addictology
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Objectives (native)
Décrire les déterminants des addictions de personnes faisant une demande d'aide pour au moins une addiction
Initial identified needs
Understanding the determining factors of addictions (substances and non-substances, legal and illegal) to identify and tackle them better.
Initial identified needs (native)
Comprendre les déterminants des addictions (substances et non-substances, légales et illégales) pour mieux les repérer et les prendre en charge
Performed by
Phénoménologie et déterminants des comportements appétitifs, addictologie et psychiatrie / Sanpsy CNRS USR 3413
Bizia, CH Cote Basques, Bayonne
Pôle Addictologie, CH Charles Perrens, Bordeaux, France
Funded by
PHRC, MILDT
Summary references
Website
Published reference(s)
Sarram S, Debrabant R, Fatseas M, Daulouède J-P, Sagapse P, Taillard J, Philip P, Auriacombe M. Changes in Sleep Quality and Alertness in Opiate-Dependent Subjects after stable Methadone and Buprenorphine Maintenance Treatment. A pilot exploratory report. Heroin Addiction and Related Clinical Problems 2013;15:39-44 Serre F, Fatseas M, Debrabant R, Alexandre JM, Auriacombe M, Swendsen J. Ecological momentary assessment in alcohol, tobacco, cannabis and opiate dependence: A comparison of feasibility and validity. Drug Alcohol Depend 2012;126:118–123 Fatseas M, Denis C, Serre F, Dubernet J, Daulouede JP, Auriacombe M. Change in HIV-HCV Risk-Taking Behavior and Seroprevalence Among Opiate Users Seeking Treatment Over an 11-year Period and Harm Reduction Policy. AIDS Behav 2012;16:2082–2090 Denis C, Fatseas M, Beltran V, Bonnet C, Picard S, Combourieu I, Daulouede JP, Auriacombe M. Validity of the self-reported drug use section of the Addiction Severity Index and associated factors used under naturalistic conditions. Subst Use Misuse 2012;47:356-63 Denis C, Fatséas M, Auriacombe M. Analyses related to the development of DSM-5 criteria for substance use related disorders: 3. An assessment of Pathological Gambling criteria. Drug and Alcohol Dependence 2012;122:22–27 Fatseas M, Denis C, Massida Z, Verger M, Franques-Reneric P, Auriacombe M. Cue-induced reactivity, cortisol response and substance use outcome in treated heroin dependent individuals. Biol Psychiatry 2011;70:720-7
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Transversal approach of the role of the subthalamic nucleus in motivation and drug addiction: from rats to parkinsonian patients

Approche transversale du rôle du noyau subthalamique dans la motivation et la dépendance aux drogues: du rat au patient parkinsonien
Funding country
France
Project starting year
2009
Project ending year
2014
Area(s) of research
Treatment responses, Consequences of drug use, Mechanism of drug use and effects
Objectives
To understand the role of the STN in the coding of the value of a reward (sucrose vs. cocaine for eg.) in intact and parkinsonian rats, in monkeys, and in Parkinson patients implanted in the STN To understand the dissociation between motivation for various rewards after handling of the STN (subthalamic nucleus deep brain stimulation in parkinsonian rats and food vs. cocaine motivation; lesion of the STN on motivation for heroin, nicotine; study of the cellular effects of HFS of the STN in the reward circuit after cocaine injection; clinical effects of HFS of the STN in parkinsonian patients with and without addiction problems or other impulse control disorders)
Scientific discipline(s) involved
Neurosciences, Pharmacology
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Objectives (native)
- Comprendre le rôle du NST dans le codage de la valeur d'une récompense (sucrose vs cocaine par ex.) chez le rat intact et parkinsonien, chez le singe, et chez le patient parkinsonien implanté dans le NST -Comprendre la dissociation entre motivation pour diverses récompenses après manipulation du NST (SHF du NST chez rat parkinsonien et motivation nourriture vs cocaine; lésion du NST sur motivation pour heroine, nicotine; étude des conséquences cellulaires de la SHF du NST dans le circuit de la récompense après injection de cocaïne; effets cliniques de la SHF du NST chez le patient parkinsonien souffrant ou non d'addiction ou d'autres troubles du contrôle de l'impulsivité)
Initial identified needs
Lesion data in rats showing a possible beneficial effect of the inactivation of the subthalamic nucleus (STN) in the treatment of cocaine addiction. Clinical data showing that in 2 patients suffering from addiction to their dopaminergic treatment, high frequency stimulation (HFS) of the STN could block their addiction.
Initial identified needs (native)
Données lésionnelles chez le rat montrant une effet bénéfique potentiel de l'inactivation du noyau subthalamique (NST) dans le traitement de la dépendance à la cocaïne. Données cliniques montrant que chez 2 patients souffrant de dépendance à leur traitement dopaminergique, la stimulation à haute fréquence (SHF) du NST pouvait bloquer leur addiction.
Performed by
Équipe BAGAMORE (C. Baunez), INT, CNRS & AMU UMR7289
Equipe de Neuropsychopharmacologie de l'Addiction (M. Cador), INCIA-Institut de Neurosciences Cognitives et Intégratives d'Aquitaine-UMR CNRS & Bordeaux univ 5287
Service de Neurologie de l'Hôpital de la Timone (JP Azulay, rattachés à l'équipe BAgamore depuis janvier 2012)
Funded by
ANR Programme MNPS 2009, Fondation de France
Summary references
Pelloux Y and Baunez C (2013) Deep brain stimulation for addiction : why the subthalamic nucleus should be favored. Curr. Op. Neurobiol. 23: XX-XX; http://dx.doi.org/10.1016/j.conb.2013.02.016
Website
Published reference(s)
Lardeux S., Paleressompoulle D., Pernaud R., Cador M., Baunez C. (2013) Different populations of subthalamic neurons encode cocaine and sucrose reward and predict error J. Neurophysiol. Online july 17
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ABSTINENCE- Mood disruption in prolonged abstinence from drugs of abuse: molecular mechanisms and gene discovery in the dorsal raphe

ABSTINENCE- Déficits émotionnels dans l’abstinence prolongée aux drogues d’abus : mécanismes moléculaires et nouveaux gènes dans le raphe dorsal
Funding country
France
Project starting year
2012
Project ending year
2015
Area(s) of research
Treatment responses
Objectives
Altogether this project will address a critical, yet poorly understood aspect of drug abuse that has not been modeled previously in animal research (1). In addition, the proposal will investigate dysfunction of serotonergic transmission in drug abuse, which remains a virtually unexplored field. The genome-wide analysis of molecular plasticity in the DRN (2) and the functional study of mu and kappa opioid receptors (3) provide both exploratory and hypothesis-driven approaches to molecular mechanisms of drug abstinence. Findings from this proposal will open novel avenues in both addiction and depression research representing two major fields in molecular psychiatry.
Scientific discipline(s) involved
Neurosciences, Pharmacology, Other medical sciences
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Objectives (native)
ce projet vise à élucider un aspect critique mais très mal connu des comportements addictifs, et qui n’a pas été modélisé chez l’animal (1). De plus, le projet examinera le dysfonctionnement de la transmission sérotoninergique dans la toxicomanie, qui est virtuellement inexploré. L’analyse à l’échelle du génome des régulations moléculaires dans le NRD (2) et l’étude fonctionnelle des récepteurs mu et kappa (3) combinent une approche exploratoire et une approche candidate dans le projet. Les résultats ouvriront des nouvelles voies de recherche dans l’étude des addictions et de la dépression, deux domaines de recherche majeurs en psychiatrie moléculaire.
Initial identified needs
Drug abuse is a chronic relapsing disorder with devastating consequences for individuals and their social environment. A major challenge in recovering from addiction is to maintain a drug-free state, also referred to as abstinent state. Prolonged abstinence is characterized by lowered mood and a negative affective state. These emotional dysfunctions are considered to contribute to relapse, and clinical studies show a marked co-morbidity between addiction and depressive disorders. However, the “abstinence syndrome” has received little attention in preclinical investigations, and the neurobiology of this particular brain state is poorly understood. The present project will capitalize on a unique mouse model to identify molecular and circuit mechanisms underlying mood disruption in protracted abstinence from drugs of abuse. Hence we will examine heroin-induced abstinence syndromes in dorsal raphe-conditional knockout mice, both at behavioral and molecular levels.
Initial identified needs (native)
Problématique: Maintenir un état d’abstinence, afin de briser le cercle vicieux de l’addiction. Le défi majeur pour un toxicomane est de vivre sans drogue, un état que l’on qualifie d’abstinent. L’abstinence prolongée se caractérise par des troubles de l’humeur qui contribuent fortement à la rechute (voir illustration). Pourtant, le « syndrome d’abstinence » est très peu étudié en recherche préclinique, et la neurobiologie de cet état particulier est très peu comprise. Notre projet vise à développer et exploiter un nouveau modèle comportemental d’abstinence prolongée chez la souris, après une exposition chronique aux drogues d’abus, notamment l’héroïne. Ce modèle permettra d’étudier les mécanismes moléculaires impliqués dans l’apparition de comportements de type dépressifs au cours de l’abstinence. Nous étudierons en particulier la cinétique de ces phénomènes, et nous nous focaliserons sur le noyau du raphé dorsal, une petite région cérébrale jouant un rôle majeur dans la régulation de l’humeur.
Performed by
Institute of Genetic & Molecular Biology (INSERM, CNRS, UdS: French National institute for health and medical research, French National centre for scientific research,Strasbourg University)
Funded by
ANR, INSERM/CNRS/Université de Strasbourg
Summary references
Website
voir site ANR
Published reference(s)
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Health and social environnement of adolescent school children

Santé et environnement social des élèves
Funding country
France
Project starting year
2010
Project ending year
2015
Area(s) of research
Prevalence, incidence and patterns of drug use, Determinants of drug use, Consequences of drug use, Mechanism of drug use and effects
Objectives
The purpose of this project is to examine the evolution of secondary school children with regard to life events (including socio-economic and family ones) and various problems related to behaviours and health, in order to determine the processes that connect them. The main targets are: - substance use (tobacco, alcohol, cannabis and other drugs) - obesity and overweight, - sport, physical, cultural, recreational activities and sedentary life, - mental health, including anxiety and depression, - accidents inside or outside the school, - sexual abuse - inflicted or suffered violence, - learning difficulties and school failure, - state of health, fatigue, sleep disturbances, - quality of life, - life projects, - suicidal ideas and suicide attempts.
Scientific discipline(s) involved
History, Sociology, Other medical sciences
Read more…
Objectives (native)
Le but de ce projet est d'étudier la trajectoire des collégiens en termes d'événements de vie (dont socio-économiques et familiaux) et divers problèmes relatifs aux comportements et à la santé, pour déterminer les processus qui les relient. Les cibles principaux sont : - la consommation de substance (tabac, alcool, cannabis et autres drogues), - l’obésité et le surpoids, - les activités physiques et sportives, culturelles, de loisirs et sédentarité, - la santé mentale dont l’anxiété et la dépression, - les accidents à l’intérieur ou hors de l’établissement scolaire, - l’abus sexuel, - la violence perpétrée et subie, - les difficultés d’apprentissage et l’échec scolaire, - l’état de santé, fatigue, troubles de sommeil, - la qualité de vie, - les projets de vie, - l’idée et les tentatives de suicide.
Initial identified needs
Many health or behaviours problems begin in adolescence, sometimes futher to family events or life difficulties (including a precarious lifestyle). Problems such as substance use starts in the first half of adolescence and may worsen and continue into adulthood. Consequences impact health, social inclusion and social costs. It is therefore important to study their early onset and historical causal process. However, researches focusing on historical reconstruction of family, socio-economic, school, behaviour, violence and health problems are rare, especially those focused on the first period of adolescence. These problems can be studied at national level. But it may be useful to first address them in a smaller regional context and a less heterogeneous population, given significant regional disparities. We have therefore limited our search to the exhaustive population of a large geographical area in the town of Nancy, including about 38,000 inhabitants and about 1,700 secondary school children. The field survey was carried out in 2010. The principal investigators are Dr. Chau Kenora and Mr Chau Nearkasen. The prevalence of behavioural problems related to health is close to the French national prevalence (ESPAD 2003).
Initial identified needs (native)
Beaucoup de problèmes de santé ou de comportements débutent à l'adolescence, parfois après des événements familiaux et suite aux difficultés de vie (dont la précarité). Certains problèmes comme la consommation de substance s'installent même à la première moitié de l'adolescence, puis peuvent s'aggraver et se poursuivre à l'âge adulte. Les conséquences concernent la santé, l'insertion sociale, et les coûts sociaux. Il est donc important d'étudier leur survenue précoce et les processus chronologiques de causalité. Cependant, les recherches incluant la reconstruction historique des problèmes familiaux, socio-économiques, scolaires, de comportements, de violence, et de santé sont rares, en particulier dans la première période d'adolescence sont plutôt rares. Ces problèmes peuvent être étudiés à l'échelon national. Mais, il est peut-être utile de les aborder d'abord dans un contexte régional, plus restreint, sur une population moins hétérogène liée notamment aux disparités régionales importantes. Nous avons donc limité notre recherche à la population exhaustive d'une vaste zone géographique dans l'agglomération de Nancy, incluant environ 38.000 habitants et environ 1700 collégiens. L'enquête sur le terrain a été réalisée en 2010. Les principaux investigateurs sont Dr Chau Kenora et M. Chau Nearkasen. La prévalence des problèmes de comportements et relatifs à la santé est proche de la France (enquête ESPAD 2003).
Performed by
Université de Lorraine, Service of Pedopsychiatry, Hôpital d'Enfants de Nancy-Brabois, Vandoeuvre-lès-Nancy, France
University of Luxembourg, INtegrative research unit on Social and Individual DEvelopment (INSIDE), Walferdange, Luxembourg
Funded by
Summary references
Les travaux réalisés sur l'enquête sont : Articles dans des revues et ouvrages internationaux : 1. Chau K, Kabuth B, Baumann M, Chau N. Quality of life social disparities and roles of family and unhealthy behaviours among adolescents. Psychology & Health 2011;26 Suppl 2:147. (Abstract). 2. Chau K, Kabuth B, Baumann M, Chau N. School difficulties in immigrant adolescent students and roles of socioeconomic factors, unhealthy behaviours, and physical and mental health. BMC Public Health 2012;12:453. doi: 10.1186/1471-2458-12-453. [http://www.biomedcentral.com/1471-2458/12/453]. 3. Chau K, Baumann M, Vauthier JC, Kabuth B, Chau N. Associations of unhealthy behaviors and depressive symptoms with school difficulties and role of socioeconomic factors in early adolescence. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013. Congress proceeding, ISBN: 978-989-97866-0-8 © 2013:134-138. 4. Chau N, Chau K, Vauthier JC, Kabuth B, Baumann M. Impact of socioeconomic, family, school, behavioural and mental difficulties on involvement in violence in boys and girls. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013, Congress proceeding, ISBN: 978-989-97866-0-8 © 2013:240-244. 5. Chau K, Baumann M, Chau N. Socioeconomic inequities patterns of multi-morbidity in early adolescence. Int J Equity Health 2013, sous presse. Présentations dans des congrès internationaux 6. Chau K, Kabuth B, Baumann M, Chau N. Quality of life social disparities and roles of family and unhealthy behaviours among adolescents. 25th Conference of the European Health Psychology Society, Crete, Greece, 20th-24th September 2011. (Présentation orale). 7. Chau K, Baumann M, Kabuth B, Chau N. Failure of school project: the role of social, material, behavioural, physical and mental resources among multi-cultural students. The 40th World Congress of the International Institute of Sociology, New-Delhi, India, 16-19 février 2012. (Présentation orale). 8. Baumann M, Chau K, Kabuth B, Chau N. Suicide behaviors and role of family characteristics, school difficulties, unhealthy behaviors, and mental health among multi-cultural students. The 40th World Congress of the International Institute of Sociology, New-Delhi, India, 16-19 février 2012. 9. Chau N, Chau K, Baumann M, Kabuth B. Do relative socioeconomic deprivations impact on subjective health-related quality of life and behaviors among adolescents? The 40th World Congress of the International Institute of Sociology, New-Delhi, India,16-19 février 2012. (Présentation orale). 10. Chau K, Kabuth B, Baumann M, Chau N. Gender disparities of depressive mood and roles of family factors, school difficulty, violence, and unhealthy behaviours among adolescents. Second ISA Forum of Sociology, Buenos Aires, Argentina, August 1-4, 2012. (Présentation orale) 11. Chau K, Baumann M, Vauthier JC, Kabuth B, Chau N. Associations of unhealthy behaviors and depressive symptoms with school difficulties and role of socioeconomic factors in early adolescence. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013. (Présentation orale). 12. Chau N, Chau K, Vauthier JC, Kabuth B, Baumann M. Impact of socioeconomic, family, school, behavioural and mental difficulties on involvement in violence in boys and girls. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013. (Présentation orale). 13. Chau K, Vauthier JC, Kabuth B, Baumann M, Chau N. Impact of social status on the associations of psychological, social relationship and school difficulties with relationship with physician and treatment adherence in primary care among adolescents. 21st IUHPE (International Union for Health Promotion and Education) World Conference on Health P
Website
Non
Published reference(s)
Les travaux réalisés sur l'enquête sont : Articles dans des revues et ouvrages internationaux : 1. Chau K, Kabuth B, Baumann M, Chau N. Quality of life social disparities and roles of family and unhealthy behaviours among adolescents. Psychology & Health 2011;26 Suppl 2:147. (Abstract). 2. Chau K, Kabuth B, Baumann M, Chau N. School difficulties in immigrant adolescent students and roles of socioeconomic factors, unhealthy behaviours, and physical and mental health. BMC Public Health 2012;12:453. doi: 10.1186/1471-2458-12-453. [http://www.biomedcentral.com/1471-2458/12/453]. 3. Chau K, Baumann M, Vauthier JC, Kabuth B, Chau N. Associations of unhealthy behaviors and depressive symptoms with school difficulties and role of socioeconomic factors in early adolescence. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013. Congress proceeding, ISBN: 978-989-97866-0-8 © 2013:134-138. 4. Chau N, Chau K, Vauthier JC, Kabuth B, Baumann M. Impact of socioeconomic, family, school, behavioural and mental difficulties on involvement in violence in boys and girls. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013, Congress proceeding, ISBN: 978-989-97866-0-8 © 2013:240-244. 5. Chau K, Baumann M, Chau N. Socioeconomic inequities patterns of multi-morbidity in early adolescence. Int J Equity Health 2013, sous presse. Présentations dans des congrès internationaux 6. Chau K, Kabuth B, Baumann M, Chau N. Quality of life social disparities and roles of family and unhealthy behaviours among adolescents. 25th Conference of the European Health Psychology Society, Crete, Greece, 20th-24th September 2011. (Présentation orale). 7. Chau K, Baumann M, Kabuth B, Chau N. Failure of school project: the role of social, material, behavioural, physical and mental resources among multi-cultural students. The 40th World Congress of the International Institute of Sociology, New-Delhi, India, 16-19 février 2012. (Présentation orale). 8. Baumann M, Chau K, Kabuth B, Chau N. Suicide behaviors and role of family characteristics, school difficulties, unhealthy behaviors, and mental health among multi-cultural students. The 40th World Congress of the International Institute of Sociology, New-Delhi, India, 16-19 février 2012. 9. Chau N, Chau K, Baumann M, Kabuth B. Do relative socioeconomic deprivations impact on subjective health-related quality of life and behaviors among adolescents? The 40th World Congress of the International Institute of Sociology, New-Delhi, India,16-19 février 2012. (Présentation orale). 10. Chau K, Kabuth B, Baumann M, Chau N. Gender disparities of depressive mood and roles of family factors, school difficulty, violence, and unhealthy behaviours among adolescents. Second ISA Forum of Sociology, Buenos Aires, Argentina, August 1-4, 2012. (Présentation orale) 11. Chau K, Baumann M, Vauthier JC, Kabuth B, Chau N. Associations of unhealthy behaviors and depressive symptoms with school difficulties and role of socioeconomic factors in early adolescence. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013. (Présentation orale). 12. Chau N, Chau K, Vauthier JC, Kabuth B, Baumann M. Impact of socioeconomic, family, school, behavioural and mental difficulties on involvement in violence in boys and girls. International Psychological Applications Conference and Trends (InPACT), Madrid (Spain), 26-28 April, 2013. (Présentation orale). 13. Chau K, Vauthier JC, Kabuth B, Baumann M, Chau N. Impact of social status on the associations of psychological, social relationship and school difficulties with relationship with physician and treatment adherence in primary care among adolescents. 21st IUHPE (International Union for Health Promotion and Education) World Conference on Health P
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Heroine in France. A social and cultural history of the dissemination of its use and trafficking, 1968-2004.

L’héroïne en France, une histoire sociale et culturelle de la diffusion des usages et des trafics, 1968-2004
Funding country
France
Project starting year
2013
Project ending year
2015
Area(s) of research
Prevalence, incidence and patterns of drug use, Law enforcement responses, Drug related crime responses, Determinants of drug use, Consequences of drug use, Supply and markets
Objectives
To report on the history of the phenomena related to drug use and trafficking in French urban areas in the context of a wider European epidemic ; To identify social and cultural factors underlying the circulation and valuations of heroin, as well as "intermediate" places and "mediators" or "facilitators"; To understand the process that could have been at the origin of an extended dissemination to a wide range of social backgrounds and thereby to renew the sociological understanding of this process; To identify the role of institutions in the users' "careers", particlurly the role of the prison in the criminalisation and the designation of "at-risk groups"; To inform policy makers tocontribute to the building of strategies or intervention programmes and to the qualification of local key players, to help decision making by elected officials; To make international comparisons possible with other countries and in particular European ones that have been affected by similar processes;
Scientific discipline(s) involved
Anthropology, Epidemiology, Legal sciences, Sociology
Read more…
Objectives (native)
- restituer l’historicité des phénomènes liés aux usages et trafics de drogues dans la France urbaine dans un contexte d’épidémie européenne plus large ; - repérer les facteurs sociaux et culturels sous-tendant les circulations et les valorisations d’un produit stupéfiant donné, les lieux « intermédiaires » et les « médiateurs » ou « passeurs » ; - comprendre les processus qui ont pu être à l’origine d’une diffusion élargie à un large spectre de milieux et de mondes sociaux, et par là en renouveler la compréhension sociologique ; - identifier le rôle des logiques institutionnelles dans les parcours des usagers et en particulier celui de la prison dans la criminalisation et la désignation de « groupes à risques » ; - éclairer les décideurs afin de contribuer à la construction de stratégies ou de programmes d’intervention et à la qualification des acteurs locaux, accompagner la prise de décision des élus ; - rendre possible les comparaisons à l’échelle internationale avec d’autres pays en particulier européens qui ont été touchés par des processus comparables ;
Initial identified needs
To elucidate the health and social "disaster" linked to the dissemination of heroine in 1980-90 in France. To understand the social history of the dissemation of this substance from the end of the 60s to the early 2000s.
Initial identified needs (native)
Elucidation de la "catastrophe sanitaire et sociale" en lien avec la diffusion de l'héroïne dans les années 1980-90 en France. Compréhension de l'histoire sociale de la diffusion de ce produit de la fin des années 60 au début des années 2000.
Performed by
CNRS GTM-CRESPPA
CNRS CADIS
ASUD
Funded by
ANR, ville de Paris, ville de Marseille
Summary references
http://www.agence-nationale-recherche.fr/projet-anr/?tx_lwmsuivibilan_pi2[CODE]=ANR-12-BSH1-0006
Website
non
Published reference(s)
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Intracellular signaling mechanisms implied in the effects of psychostimulants

Mécanismes de signalisamtion intracellulaire responsables des effets des psychostimulants
Funding country
France
Project starting year
-
Project ending year
2015
Area(s) of research
Consequences of drug use, Mechanism of drug use and effects
Objectives
Determining the intracellular signaling pathways activated by cocaine which are responsible for long-lasting effects, including altering transcription.
Scientific discipline(s) involved
Neurosciences, Pharmacology
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Objectives (native)
Déterminer les voies de signalisation intracellulaire activées par la cocaïne qui sont responsables d'effets durables, notamment en modifiant la transcription.
Initial identified needs
Cocaine is a "model" drug which has important. long-term behavioural effects. Understanding the molecular mechanisms related to those effects may serve pathophysiological model for addiction.
Performed by
INSERM-UPMC (French National institute for health and medical research-Pierre and Marie Curie University)
Funded by
ANR, Inserm, Communauté européenne
Summary references
Valjent E, Bertran-Gonzalez J, Aubier B, Greengard P, Hervé D, Girault JA. Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol. Neuropsychopharmacol, 2010, 35:401-15 COVER ILLUSTRATION. Jordi E, Heiman M, Marion-Poll L, Guermonprez P, Cheng SK, Nairn AC, Greengard P, Girault JA. Differential effects of cocaine on histone post-translational modifications in identified populations of striatal neurons. Proc Natl Acad Sci USA. 2013, 110:9511-6.
Website
Published reference(s)
Valjent E, Bertran-Gonzalez J, Aubier B, Greengard P, Hervé D, Girault JA. Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol. Neuropsychopharmacol, 2010, 35:401-15 Jordi E, Heiman M, Marion-Poll L, Guermonprez P, Cheng SK, Nairn AC, Greengard P, Girault JA. Differential effects of cocaine on histone post-translational modifications in identified populations of striatal neurons. Proc Natl Acad Sci USA. 2013, 110:9511-6.
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Effects of high frequency stimulation of the subthalamic nucleus on motivation for cocaine in monkeys

Effets de la stimulation à haute fréquence du noyau subthalamique sur la motivation pour la cocaine chez le singe
Funding country
France
Project starting year
2013
Project ending year
2016
Area(s) of research
Treatment responses
Objectives
To test the effects of deep brain high frequency stimulation of the STN on motivation, for monkeys, to work for applesauce or cocaine reward and thus validate the possible beneficial effect on diminishing motivation for cocaine.
Scientific discipline(s) involved
Neurosciences, Pharmacology, Other medical sciences, Psychiatry
Read more…
Objectives (native)
Tester les effets de la stimulation cérébrale profonde à haute fréquence du NST sur la motivation du singe à travailler pour de la compote ou de la cocaïne et ainsi valider, ou pas, l'effet bénéfique de réduction de motivation pour la cocaïne.
Initial identified needs
Our data in rats have shown that inactivation of the subthalamic nucleus (STN) reduces the motivation for cocaine, while increasing the motivation for natural rewards
Initial identified needs (native)
Nos données chez le rat ont montré que l'inactivation du noyau subthalamique (NST) diminue la motivation pour la cocaine, tout en augmentant la motivation pour des récompenses naturelles
Performed by
Equipe BAGAMORE, Institut de Neurosciences de la Timone, CNRS & Aix-Marseille Univ, UMR7289
collaboration internationale avec Pr Charles Bradberry (univ Pittsburgh, USA) qui agit comme consultant (visiting professor de l'AMU été 2013)
Funded by
Fondation de l'Avenir, CNRS, Aix-Marseille Université
Summary references
Pelloux Y and Baunez C (2013) Deep brain stimulation for addiction : why the subthalamic nucleus should be favored. Curr. Op. Neurobiol. 23: XX-XX; http://dx.doi.org/10.1016/j.conb.2013.02.016 Rouaud T*, Lardeux S*, Panayotis N, Paleressompoulle D, Cador M, Baunez C (2010) Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation. P. Natl. Acad. Sci. USA 107:1196-1200
Website
non
Published reference(s)
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Opioid addiction and impact of the substitution treatments

Dépendance aux opioïdes et impact des traitements de substitution
Funding country
France
Project starting year
2012
Project ending year
2016
Area(s) of research
Treatment responses, Determinants of drug use, Consequences of drug use, Mechanism of drug use and effects
Objectives
We use innovative behavioural, biochemical and molecular approaches. The main objectives are: 1) to identify the neurobiological regulations that could explain the differences between controlled and compulsive use of heroin, 2) to evaluate the effectiveness of the buprenorphine (BUP) and the methadone (METH) in preventing relapse induced by heroin, 3) to develop a more comprehensive perception of the molecular regulations induced by compulsive heroin use and the influence of substitution treatments. This project will provide new guidance on the molecular regulations underlying the differences between controlled and compulsive drug use. It will help to understand the molecular actions of BUP and METH in reducing compulsive heroin use and relapse prevention mechanisms.
Scientific discipline(s) involved
Neurosciences, Pharmacology
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Objectives (native)
Nous utilisons des approches comportementales, biochimiques et moléculaires innovantes. Les principaux objectifs sont: 1) identifier les régulations neurobiologiques pouvant expliquer les différences entre utilisation contrôlée et compulsive d'héroïne; 2) évaluer l'efficacité de la BUP et la METH dans la prévention de la rechute induite par l'héroïne, 3) développer une perception plus globale des régulations moléculaires induites par la consommation compulsive d'héroïne ainsi que l'influence des traitements de substitution. Ce projet fournira des indications tout à fait nouvelles sur les régulations moléculaires qui sous-tendent les différences entre l'usage de drogue contrôlé et compulsif. Il contribuera à élucider les mécanismes moléculaires d'action de la BUP et la METH permettant une réduction de la consommation compulsive d'héroïne et la prévention des rechutes.
Initial identified needs
In Western Europe, opioids remain the main drugs for which patients undergo treatment. Current treatments are primarily substitution treatments: methadone (METH) and buprenorphine (BUP). They have improved the users' quality of life. However, one major problem is the high rate of relapse. It is crucial to understand the molecular mechanisms of the disease and the influence of substitution treatment. METH and BUP are widely prescribed but few studies have examined their efficacy in animal models about compulsive heroin use, which has limited the identification of the molecular and cellular mechanisms of the action of these molecules. We have already shown that acute and chronic treatments with these substances induce regulations of genes distinct from those involved by morphine in rats. It is now necessary to establish a period of treatment with BUP or METH so as to study its impact on compulsive drug seeking induced by heroin in a adapted model (a self-administration model).
Initial identified needs (native)
En Europe de l'Ouest, les opioïdes demeurent les principales drogues pour lesquels les patients se font soigner. Les traitements actuels consistent principalement en des traitements de substitution : la méthadone (METH) et la buprénorphine (BUP). Ils ont permis d'améliorer la qualité de vie. Toutefois, l'un des principaux problèmes est le taux élevé de rechute. Il est crucial de mieux comprendre les mécanismes moléculaires de la maladie et l'influence des traitements de substitution. La METH et la BUP sont largement prescrits mais peu d'études ont analysé leur efficacité dans des modèles animaux de consommation compulsive d'héroïne, ce qui a limité l'identification des mécanismes moléculaires et cellulaires de l'action de ces molécules. Nous avons déjà montré que les traitements aigus et chroniques avec ces produits induisent des régulations de gènes distinctes de celles de la morphine chez le rat. Il est maintenant nécessaire de mettre en place une période de traitement à la BUP ou la METH afin d’étudier son impact sur la recherche compulsive de drogue induite par l’héroine dans un modèle adapté (un modèle d'auto-administration).
Performed by
CNRS - Neuroplasticité et Traitements des addictions
Funded by
CNRS, ANR
Summary references
Website
non
Published reference(s)
Belkaï E, Crété D, Courtin C, Noble F, Marie-Claire C. (2013) Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine. Eur J Pharmacol 711(1-3):10-18.
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Research programme and intervention to reduce the risk of infection while being in custody (PRIDE)

Programme de recherche et intervention pour la réduction du risque infectieux en détention (PRIDE)
Funding country
France
Project starting year
2013
Project ending year
2016
Area(s) of research
Prevention responses, Treatment responses, Harm reduction responses
Objectives
Assessing the feasibility and acceptability of the adjustment of infectious risk reduction measures (wider deployment of existing measures, new measures) in prisons.
Scientific discipline(s) involved
History
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Objectives (native)
évaluer la mise en oeuvre d'un ajustement des mesures de réduction des risques infectieux (meilleur déploiement des mesures existantes, mesures nouvelles) en prison en termes de faisabilité et d'acceptabilité
Initial identified needs
Deficiencies have been observed with regard to the reduction of infection risks among drug user inmates in the French prisons.
Initial identified needs (native)
Constat des carences en termes de réduction des risques infectieux pour les usagers de drogues/détenus dans les prisons françaises
Performed by
INSERM unit U669 (French National institute for health and medical research)
Cermes 3 Inserm U988
Funded by
Agence Nationale de Recherche sur le SIDA et les hépatites Virales
Summary references
Michel L, Jauffret-Roustide M, Blanche J, Maguet O, Calderon C, Cohen J, et al. Limited access to HIV prevention in French prisons (Anrs-Pri2de): implications for public health and drug policy. BMC Public Health 2011;11:400.
Website
Published reference(s)
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Social acceptability of the lower risk drug consmuption rooms in France

Acceptabilité sociale des salles de consommation à moindre risque en France
Funding country
France
Project starting year
2013
Project ending year
2016
Area(s) of research
Harm reduction responses, Consequences of drug use, Methodology issues
Objectives
To be completed
Scientific discipline(s) involved
Anthropology, Political sciences, Sociology
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Objectives (native)
- évaluer les freins à la mise en place de salles de consommation à moindre risque en France. - étudier l'évolution des représentations des riverains vis-à-vis des salles de consommations à moindre risque et vis-à-vis des usagers de drogues avant et après la mise en place du dispositif. - analyser l'acceptabilité sociale des salles de consommation à moindre risque - analyse socio-historique de la mise en place de ce dispositif en France.
Initial identified needs
Within the framework of the controversial implementation of drug consmuption rooms in France, it is essential to investigate the opinion of the local residents about the initiative of opening such drug consumption room, at the local level corresponding to the urban area in the room is located. A quantitative methodology (opinion surveys) and qualitative one (ethnographical observations, interviews) would allow to apprehend better the various dimensions of the social acceptability of this Public Health measure.
Initial identified needs (native)
Dans le cadre de la mise en place controversée de salles de consommation à moindre risque en France, il est primordial de recueillir l’opinion des riverains sur l’initiative d’une salle et sur son ouverture, à un niveau local correspondant à l’environnement urbain au sein duquel se situe la salle. Une méthodologie quantitative (enquêtes d'opinion) et qualitative (observations ethnographiques, entretiens) permet de mieux appréhender les différentes dimensions de l'acceptabilité sociale de cette mesure de santé publique.
Performed by
INSERM U988 (Cermes3)
Inserm U912
CNRS USR3413
Funded by
MILDT
Summary references
Website
Published reference(s)
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